What If...? (1977) #11

• "What If... the Fantastic Four Were the Original Marvel Bullpen?" – (Earth-1228) – Four members of the original Marvel Bullpen become subjects of an insidious experiment when a box shooting cosmic rays is delivered to their office one day in the early 60s. Granted super-powers, they dedicate themselves to hunting down the mysterious "S-People" responsible for their transformations. Over the course of two decades, they embark on secret missions as the Fantastic Four while adapting their exploits into the comics they publish by day. Meanwhile, the "S-People" continue to plant similar boxes, subjecting others to worse transformations. Eventually, the FF track the cosmic rays to Atlantis. With the help of the Sub-Mariner, they ferret out the "S-People", revealed to be their recurring enemies, the Skrulls. Together with Namor, they find the Skrull's underwater base and destroy it, ending the project to transform humanity with cosmic rays, and bringing them a step closer to restoring their own humanity.

SOURCE: marvel.wikia.com 

... In the second alternative version (Earth-78227), Betty Brant is present at the demonstration and is bitten by the spider. Once again, Parker discovers the spider and takes it into his possession. Betty confides in Parker that she has spider powers and Parker aids her in becoming a heroine, designing a costume and building her web shooters. Betty fights crime but refuses to use her spider strength in battle. However, when a criminal escapes from Betty she later finds out that he killed Ben Parker, and she punches the criminal in a rage. The blow proves to be fatal. Unable to cope with the fact that she took someone's life, Betty gives up on the life of a crime fighter and goes back to living an ordinary life.

... In the third alternative version (Earth-78327), Colonel John Jameson is bitten by the radioactive spider. As was the case in the previous two stories, Parker obtains the spider. John's father Jonah Jameson learns of his son's new powers and immediately starts to endorse him in his paper and encourages him to become a crime fighter. John agrees and dons a costume and a jet pack. Like Flash Thompson he does not develop web shooters, and when the runaway space capsule falls to Earth, he relies solely on his jet pack to slow its decent. Unfortunately, the pack is not strong enough to slow the capsule's fall and he is crushed beneath it.

NOTE: After the end of the three stories, it is explained that no matter who was bitten by the spider, Parker uses the spider's remaining venom to develop a serum that grants him spider powers and he dons the mantle of Spider-Man.

NOTE: At the end of the three stories, the three heroes' careers had came to a sudden end; Flash and John's deaths and Betty's decision of giving up being Spider-Girl after the death of Ben Parker.

SOURCE: marvel.wikia.com